1,3-Dimethylvioluric acid
5-hydroxyimino-1,3-dimethyl-1,3-diazinane-2,4,6-trione
CAS: 5417-13-0
Molecular Formula: C6H7N3O4
1,3-Dimethylvioluric acid - Names and Identifiers
1,3-Dimethylvioluric acid - Physico-chemical Properties
| Molecular Formula | C6H7N3O4 |
| Molar Mass | 185.14 |
1,3-Dimethylvioluric acid - Introduction
5-hydroxyimino-1,3-dimethyl-1,3-diazinane-2,4,6-trione, also known as 5-hydroxyimino-1,3-dimethyl-1, 3-diazepine-2, 4,6-trione, is a commonly used organic synthesis reagent. The following is a description of its nature, use, preparation and safety information:
Nature:
1. Appearance: White crystalline solid.
2. solubility: soluble in some organic solvents, such as acetonitrile and dimethyl sulfoxide.
3. Stability: Stable at room temperature, but may be decomposed by moisture and light.
Use:
1. coupling reagent: 5-hydroxyimino-1,3-dimethyl-1,3-diazinane-2,4,6-trione is often used as a coupling reagent between phenylacetic acid or acid chloride and amino alcohol, and is used for amidination reaction or amide formation reaction in organic synthesis.
2. Activating reagent: It can also be used as an activating reagent for carboxylic acid, reacting with carboxylic acid to generate activated amide intermediates, which is convenient for further functional group conversion.
Preparation Method:
The preparation method of 5-hydroxyimino-1,3-dimethyl-1,3-diazinane-2,4,6-trione is mainly carried out by acid-catalyzed reaction. One commonly used method is the reaction of 5-hydroxyimine-1, 3-dimethyl-1, 3-diazepine-2, 4,6-trione with chloroformic acid, DCC (dicyclohexylcarbodienecarbamate) and methylene propionitrile in the presence of sodium carbonate.
Safety Information:
1. 5-hydroxyimino-1,3-dimethyl-1,3-diazinane-2,4,6-trione may cause irritation to eyes, skin and respiratory tract, and protective measures should be taken when contacting.
2. in use, attention should be paid to avoid inhalation of dust and avoid contact with strong oxidants.
3. storage should be sealed in a dry, cool, ventilated place, away from fire and heat sources.
Please note that this information is for reference only. Before using 5-hydroxyimino-1,3-dimethyl-1,3-diazinane-2,4,6-trione, please make sure to read the relevant chemical safety instructions carefully and follow appropriate operation measures.
Nature:
1. Appearance: White crystalline solid.
2. solubility: soluble in some organic solvents, such as acetonitrile and dimethyl sulfoxide.
3. Stability: Stable at room temperature, but may be decomposed by moisture and light.
Use:
1. coupling reagent: 5-hydroxyimino-1,3-dimethyl-1,3-diazinane-2,4,6-trione is often used as a coupling reagent between phenylacetic acid or acid chloride and amino alcohol, and is used for amidination reaction or amide formation reaction in organic synthesis.
2. Activating reagent: It can also be used as an activating reagent for carboxylic acid, reacting with carboxylic acid to generate activated amide intermediates, which is convenient for further functional group conversion.
Preparation Method:
The preparation method of 5-hydroxyimino-1,3-dimethyl-1,3-diazinane-2,4,6-trione is mainly carried out by acid-catalyzed reaction. One commonly used method is the reaction of 5-hydroxyimine-1, 3-dimethyl-1, 3-diazepine-2, 4,6-trione with chloroformic acid, DCC (dicyclohexylcarbodienecarbamate) and methylene propionitrile in the presence of sodium carbonate.
Safety Information:
1. 5-hydroxyimino-1,3-dimethyl-1,3-diazinane-2,4,6-trione may cause irritation to eyes, skin and respiratory tract, and protective measures should be taken when contacting.
2. in use, attention should be paid to avoid inhalation of dust and avoid contact with strong oxidants.
3. storage should be sealed in a dry, cool, ventilated place, away from fire and heat sources.
Please note that this information is for reference only. Before using 5-hydroxyimino-1,3-dimethyl-1,3-diazinane-2,4,6-trione, please make sure to read the relevant chemical safety instructions carefully and follow appropriate operation measures.
Last Update：2024-04-09 15:18:01
